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KMID : 0614619920240020275
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Korean Journal of Gastroenterology
1992 Volume.24 No. 2 p.275 ~ p.283
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Lipoprotein(a) in patients with Various Liver Diseases
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함기백
김원호/한광협/전재윤/강진경/박인서/최홍재/김치정/김한수
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Abstract
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Lipoprotein (a) [Lp (a)] is a LDL-like lipoprotein whose concentrations in plasma are significantly are correlated with atherosclerosis. The characteristic protein compoment of Lp (a) is apoliporotein (a) which is linked to apolipoprotein B-100
by
disulfide bonds. Although Lp (a) might play an important role in the development of premature atherosclerotic vascular lesions, only scarse information about the metabolism of this lipoprotein is availble. The major site of synthesis of Lp (a)
appers to
be the liver because it was found that a complete conversion of the Lp (a) phenotype of the receipient to that of the donor occurs after liver transplantation and presence of apo (a) mRNA in human liver and hepatoma cell line. Until the present
time,
little information is available about determining the influence of liver distase on Lp (a) concentration This study was designed to fine out the changes of Lp (a) concentrations in 88 patients with various liver diseases, diagnosed histologically
through the peritoneoscopic liver biopsy. The Lp (a) concentrations were checked by the method of radioimmunoassay. The mean Lp (a) concentrations of CAH with LO (6.1±4.8㎎/ml) and LC group (4.1±2.2㎎/ml) were significantly lower than those of
normal
control (24.4±19.1㎎/ml), CPH (25.4±18.5㎎/ml), and CAH group (16.6±13.7㎎/ml). The Lp (a) concentrations were significantly correlated with serum albumin concentrations (r=0.54 p<0.05) and prothrombin time (r=0.62 p<0.01). there was a
significant
difference in mean Lp (a) coincentration between the cases with serum albumin above and below 3.0g/ml in patients with liver cirrhosis. These data suggest that lipoprotein (a) may be secreted from the liver in accordance with the capability of
live
to
synthesize the protein and we find out that as the liver diseases progressed and deteriorated, the levels of Lp (a) concentrations were significantly decreased.
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